Erythropoiesis
The first erythrocytes contain nuclei and derive from stem cells (BFU/CFU-E) that arise in the blood islands of the umbilical vesicle. Centrally lying cells of these blood islands join up thereby into nucleus-containing, large erythroblasts, whereas those peripherally located become endothelial cells. One also calls this extraembryonic phase of the blood formation megaloblastic eryhropoiesis.
This extraembryonal erythropoiesis is supplanted by thee embryonic erythropoiesis, which arises in the liver. These stem cells have their origin in the aorto-gonado-mesonephros region. The erythrocytes that arise in the liver are nucleus-free - in contrast to those formed outside the embryo - and are produced there up to the 28th week of pregnancy-
A small portion is also formed in the spleen (green in Figure 3). This hepatolienal phase dominates the second trimenon of the pregnancy.
In the last trimenon the bone marrow is the most important hematopoietic organ (myeloid phase of the erythropoiesis).
Note:
- Number of erythrocytes per ml blood: ca. 5 millions
- Diameter of the erythrocytes: 7.5 µm
- Life expectancy: ca.120 days (at birth ca. 40-70 days)
Hemoglobin
Hemoglobin in human erythrocytes consists of 2 paired globin chains that are arranged around a heme that, for its part, can bind oxygen..
While only hemoglobin of the Hb Gower 1 (ζ2ε2) type with ζ and ε chains is formed in the blood islands of the umbilical vesicle, the mature erythrocyte of the hepatic phaseε exhibits mainly HbF (α2γ2), the globin of which possesses α and γ chains and represents the most important fetal hemoglobinγ
Following birth, the fetal HbF (α2γ2) is slowly replaced by the adult HbA1 (α2β2). This consists of alpha and beta chains and represents the most important adult hemoglobin. In addition there is still a small portion of HbA2(α2δ2) that exhibits δ chains instead of β ones.