The lymphatic tissue of the intestines, Peyer's plaque, and the vermiform appendix appear clearly later than the tonsillar anlage, namely only in the second half of the pregnancy. Initially, accumulations of lymphocytes gather, mainly in the ileum, where they accumulate in the submucosa at various locations and thus mark the beginning of the formation of Peyer's plaque. The first primary follicles appear in the 7th to 8th months.
In the cecum region - between the 4th and 5th month - the first accumulations of lymphatic cells have also been shown to be present immediately below the intestinal epithelium. Here, the close relationship to the intestinal epithelium that lies just above it is especially pronounced.
In the lung anlage, which also has an endodermal origin, the lymphatic tissue develops still later. The first lymph nodes form only after the 7th month. One can recognize primary follicles only in the 8th month.
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