The prostate develops from a protrusion on the dorsal wall of the prostatic part of the urethra during the 12th week. The prostate's glandular epithelium develops, therefore, from cells that have their origin in the endoderm, while the stroma and smooth muscle develops from cells with a mesodermal origin - under the inducing influence of DHT (see: hormonal factors in sex differentiation). The glands become active after the 15th week and surround the two ejaculatory ducts and the prostatic utricle as well as the prostatic part of the urethra.
Over the course of the 12th week and parallel to the development of the prostate, bulbourethral (Cowper's) and urethral (Littre's) glands form, originating in pairs of endodermal protrusions of the spongy part of the urethra, which follow from the prostatic membranous parts. Finally, the seminal fluid is augmented by secretions from the seminal vesicle, the prostate, the bulbourethral and urethral glands.
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Fig. 38 - Male urethra with
accessory glands |
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Legend |